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NGS 2015 Sheffield

October 12, 2015 - October 13, 2015

NGS 2015 Sheffield

Conference: 18 - 19 November

The third annual Next Generation Sequencing Conference in Sheffield took at Halifax Hall, Sheffield University on 18th & 19th November 2015 and it was in partnership with the Sheffield Children’s NHS Foundation Trust and the University of Sheffield.

DNA helix against the colored backgroundThis year’s event brought together leading genomics researchers and clinicians who use Next Generation Sequencing  in the analysis or diagnosis of human diseases. Speakers discussed their latest genomic research in rare diseases and cancer as well as specific application areas such as Exome/Genome Sequencing, RNA Seq, Epigenetics and analysis of limiting sample amounts.

Whilst advances in these areas are being made and indeed were discussed at the conference, the usual data analysis and storage bottlenecks remain and delegates heard how some of these issues are beginning to be solved.

In addition to the excellent science NGS 2015 Sheffield was characterized by a collaborative air where all delegates got the chance to interact with each other during networking events including at the networking dinner on the evening of 18th November at Halifax Hall.



09.00 – 10.30: Registration, Coffee & Networking
10.30 – 11.00: OPENING – Darren Grafham, Sheffield Diagnostic Genetics Service, Sheffield Children’s NHS Foundation Trust
11.00 – 11.30: Networking and Collaborations by Dr Ed Quazi
11.30 – 12.00: Dr Kim Brugger, Lead Bioinformatician, Addenbrookes Hospital, Cambridge Strategy for validating the ever-changing face of next generations sequencing
12.00 – 12.30: Prof Anthony J. Brookes, Genetics, University of Leicester Discovering Data Discovery
12.30 – 13.30: Lunch, Exhibition & Networking
13.30 – 14.00:  Dr Ian Berry, Registered Clinical Scientist, Leeds Genetics Laboratory Panels, to Mendeliome, to Exome – Simple Analytical Solutions for a Simple World
14.00 – 14.30: Dr Mike Quail, Sequencing R&D, Wellcome Trust Sanger Institute Sequencing Technology
15.00 – 15.30:  Refreshments, Exhibition & Networking
15.30 – 16.00: Dr Marc-Emmanuel Dumas, Translational Systems Biomedicine, Computational & Systems Medicine, Surgery & Cancer, Imperial College London Integrating Metabolic Phenotypes with Metagenomic Sequences to Study The Human Gut Microbiome in Health and Disease
16.00 – 16.30: Dr Eran Elhaik, Bioinformatics Hub, University of Sheffield Localizing the admixture signatures of Yiddish speakers to primeval villages in ancient Ashkenaz lands
16.30 – 17.30:   PANEL DEBATE – Screening of Populations and the Ethics of using Genetic Information hosted by Darren Grafham, Sheffield Children’s NHS Trust


09.00 – 09.30: Dr Clare Gladding, Research Project Manager, Sheffield Diagnostic Genetics Service, Sheffield Children’s NHS Foundation Trust Applications of Next Generation Sequencing in Newborn Screening
09.30 – 10.00: Dr Hywel Williams, Centre for Translational Omics, GOSgene, UCL Institute of Child Health Rapid Paediatric Sequencing (RaPS): Challenges to overcome
10.00 – 10.30: KEYNOTE – Prof Colin Cooper, Cancer Genetics, Norwich Medical School The natural history of development of Prostate Cancer
10.30 – 11.00: Coffee, Exhibition & Networking
11.00 – 11.30: KEYNOTE – Prof Eamonn Sheridan, Clinical Genetics, Leeds Institute for Molecular Medicine Next Generation Sequencing. What can we do now and in the next generation?
11.30 – 12.00: Dr Christopher Woelk, Reader in Genomics & Bioinformatics, Faculty of Medicine, Southampton General Hospital, University of Southampton Gene expression analysis of TIL rich HPV driven head and neck tumours reveals a distinct B-cell signature when compared to HPV independent tumors
12.00 – 12.30:  Dr David Buck, Head of High-Throughput Genomics, Oxford Genomics Centre, University of Oxford High Impact Sciences deserves High Impact Support at the Bleeding Edge of Technology
12.30 – 13.30: Lunch, Exhibition & Networking
13.30 – 14.00: Dr Clive Mulatero, Molecular Oncology, Leeds Teaching Hospitals NHS Trust 100,000 Genomes Project and NHS transformation in Genomic Medicine
14.00 – 14.30:  Dr Matt Loose, Medicine & Health Sciences, University of Nottingham Running and Reading in Real Time: Looking at Squiggles on the Oxford Nanopore minION
14.30 – 15.00: Refreshments, Exhibition & Networking
15.00 – 15.30: Dr Mike Hubank, Scientific Director, UCL Genomics Methylation Profiling for diagnostics and discovery in a translational research facility
15.30 – 16.00: Dr Andrea Haworth, Head of Clinical Service, Congenica Genome Analytics in the Clinic



Sophia Genetics, a European leader in Data Driven Medicine, brings together expertise in clinical genetics, bioinformatics, machine learning, and genomic privacy. Based in Switzerland, we are known for our high medical standards and Swiss precision when it comes to accuracy and quality management. Sophia Genetics offers health professionals who perform clinical genetic testing bioinformatics analysis, quality assurance, and secure banking of patient DNA sequence data generated by NGS. Sophia Genetics helps clinical laboratories to reduce the cost, overcome complexity and fulfill quality constraints related to the use of NGS in the clinic. www.sophiagenetics.com


diagnodeDiagenode Corporation is a global Epigenetic company and Diagnostics assay manufacturer based in Liège, Belgium and Denville, NJ, USA. Diagenode offers the most comprehensive range of Epigenetic products in the world, amongst its product portfolio are the famous Bioruptor® Shearing devices, Premium® and Blueprint® antibodies, IP-Star® automated workstations and many reagents. From Diagenode’s founding in 2003 in Liège as a local Biotechnology startup, the company has expanded rapidly. Diagenode has opened its US branch in 2006 and developed a distribution and partnering network across the entire world with strong anchorages in Japan and other Asia-Pacific countries. Diagenode has been profitable since its creation. The company planned to develop extensively its range of innovative products in both the Epigenetics and Infectious diseases markets. In October 2013, Diagenode’s headquarters have moved into a brand new facility near to the Univeristy of Liège’s campus.

newmarket-scientific-logo-and-bioo-logo-1Newmarket Scientific is the UK and Ireland distributor for Bioo Scientific the provider of NEXTflex™ NGS Library prep kits and barcodes for DNA-Seq, RNA-Seq, qRNA-Seq, directional RNA-Seq, Small RNA-Seq, Amplicon-Seq, Mitochondrial DNA-Seq and many more dedicated application kits including target capture. Bioo Scientific’s NEXTflex™ Sequencing Kits and Barcodes feature enhanced adapter ligation technology giving the best ligation and amplification efficiency available in a library preparation kit ensuring minimal bias and maximum coverage.

newgene-logoEstablished through a partnership between the Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, NewGene is a pioneer in developing, validating and delivering molecular diagnostics using the latest high throughput sequencing and genotyping technologies. NewGene’s core team has a background in molecular genetics within the NHS. By combining this clinical and laboratory expertise with the use of high throughput sequencing platforms, NewGene is able to deliver a high quality, fast turnaround service at an attractive price. NewGene works in collaboration with clinicians and scientists to deliver optimal services to regional and national NHS Trusts and overseas healthcare providers. NewGene also works closely with the NHS and pharmaceutical companies on the validation of biomarkers and the development of diagnostic tests for personalised medicine to ensure access to leading clinical services.

personalis-logoPersonalis, Inc. provides researchers and clinicians accurate DNA sequencing and interpretation of human exomes and genomes. We support researchers engaging in case-control, family-based, or proband-only genomic studies of disease, pharmacogenomics, and cancer. Our ACE (Accuracy and Content Enhanced) Technology supplements a standard exome or genome, substantially increasing its medically-relevant coverage and accuracy. Personalis builds on this enhanced sequencing foundation with innovative algorithms and proprietary databases for alignment, variant calling, annotation, and analysis. Through this comprehensive approach, we provide genomic data and interpretation of the highest accuracy. The company’s clinical laboratory is CLIA licensed and CAP accredited.

multiplicom-logo2Multiplicom develops, manufactures and commercializes molecular diagnostic assays, provided as kits, which enable personalized medicine. Founded in 2011 as a spin-off from the University of Antwerp and VIB, Multiplicom achieved end of 2012 its first CE-IVD-certification for the BRCA MASTR Dx assay for breast and ovarian cancer predisposition. It was the first company in Europe achieving a BRCA CE-IVD certification and it continues to develop and market quality controlled MPS-based assays. Therefore, it enables clinical laboratories to diagnose patients with a genetic disease or predisposition, steer cancer therapy, and identify congenital defects early in pregnancy. The Multiplicom N.V. site, located at Galileïlaan 18 in Niel, Belgium, operates a Quality Management System to design, develop, manufacture and distribute CE-IVD products according to ISO 13485:2012.




Endcliffe Vale Road
S10 3ER
Tel:  0114 222 8810

The Halifax Hall is situated within the Endcliffe Village which is part of the University of Sheffield, it’s located just a ten minute drive from Sheffield city centre and offers free car parking to all guests.


Halifax Hall is also close to a very reliable bus route that runs through the city centre with buses running every 20 minutes to the train and bus station (bus route 120).

You can find a detailed map of the Endcliffe Village here:  Halifax Hall Map Directions


Sheffield can be easily reached by air, train and road:


Robin Hood Doncaster Sheffield, one of the youngest airports in the UK and operates some international flights.  WizzAir offers direct connections with Warsaw, Gdańsk, Katowice, Poznań, Vilnius and Wrocław.

Nottingham East Midlands Airport is approximately one hour south of Sheffield on the M1 motorway. There are several daily bus services between Sheffield and the airport, operated by GorillaBus and National Express.

Manchester Airport is located around 45 miles away Sheffield and it is served by a direct train connection to Sheffield. Manchester airport offers the widest choice of long haul destinations in the north of England.

Leeds Bradford Airport offers numerous can be reached in around an hour by car and a little more by train and bus from Sheffield via Leeds.


There are twice hourly high-speed services to and from London St. Pancras (Via Derby/Nottingham, and Leicester) operated by East Midlands Trains.  Sheffield also lies near the heart of Britain’s cross country rail network, with twice hourly services from the south, south-west and midlands (Devon, Dorset, Berkshire and the West Midlands) to the north-east and Scotland (Tyne and Wear, Edinburgh, Aberdeen).  All long-distance north-south services that do not call in London are operated by Cross Country Trains.  Sheffield is also at the centre of a large and well-served west (Lancashire, Merseyside, Greater Manchester, Manchester Airport) to east (Lincolnshire, East Riding of Yorkshire, Norfolk) network. Please visit  www.nationalrail.co.uk for train times and prices.


Sheffield Interchange is the city’s hub for local and national bus services, and is located two minutes walk from Sheffield’s railway station. National Express operate long distance services to all parts of the country, including a regular service to London Golders Green and Victoria.

For more details please visit:  www.nationalexpress.com


Sheffield sits beside the M1 motorway and is most easily reached from junction 33, which connects to the city centre via the Sheffield Parkway.  A convenient park and ride tram stop is located close to the city end of the Parkway, and if you’re only visiting for the day, you are strongly recommended to use it.

Fifteen miles further north on the M1, you can connect with the M62, the main route from places (North Wales, Liverpool and Manchester) and east (Hull ferries to mainland Europe).

NGS 2015 Sheffield

Conference: 18 – 19 November

Halifax Hall, Sheffield University

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October 12, 2015
October 13, 2015

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