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NGS 2013 Manchester

November 5, 2013 - November 6, 2013

NGS 2013 Manchester

Conference: 5th - 6th November


This event took place in November 2013

The aim of our Next Generation Sequencing conference is to address key issues being faced by clinical genetics laboratories as well as other labs that are implementing Next Generation Sequencing (NGS). Whilst NGS is a very powerful technology that holds the promise of unlocking the secrets of DNA sequences on a large scale, its implementation has not been as smooth as anticipated.

Our previous NGS Workshop & Symposium in Oxford focused on bioinformatics alone, whereas the current NGS conference in Manchester will take the theme a step further by looking at bioinformatics as well as other related topics. Issues which have become recognized bottlenecks within NGS applications include but are not limited to Sample Preparation/Library Generation, Bioinformatics Data Analysis and Data Storage.

The NGS 2013 Manchester conference will bring together leading experts from widely diverse backgrounds to tackle these matters by networking, discussing the common bottlenecks and working with each other to try and mitigate these issues. Researchers working in the areas of micro RNA’s, Exome & Genomic sequencing, NGS panels, inherited diseases, expression analysis, viral genomics to name but a few areas can now listen to each other and find effective strategies and partners.

The programme includes workshops and talks in:

  • Bioinformatics Data Analysis
  • Data Visualization
  • Predicting Functional effects of DNA variants
  • Sample Preparation



08.00 – 09.30: Registration, Coffee and Networking
09.00 – 10.00: WORKSHOP – “An introduction to Genome Wide Association Scans and Next Generation Sequencing ” Dr Paul Denny, Gene-Effects
10.00 – 10.45: Prof Tim Aitman, Clinical and Molecular Genetics, Imperial College, London TITLE: Implementing NGS in research and the clinic
10.45 – 11.15: Refreshments, Exhibitions and Networking
11.15 – 11.45: Dr Clark Mason, BD Biosciences TITLE: Cell isolation by Flow Cytometry for Next Gen Sequencing and Sequence Detection
11.45 – 12.15: Dr Jonathan Strefford, Associate Professor Cancer Molecular Genetics, University of Southampton TITLE: The application of high-throughput sequencing to the study of mature B-cell malignancies
12.15 – 12.45: Dr Varsha Khodiyar, Editorial Biocurator, F1000Research TITLE: Challenges for the publication and peer review of NGS data
12.45 – 13.45: Lunch, Exhibitions and Networking
13.45 – 14.45: TECHNOLOGY WORKSHOP – “Enhanced solution based target enrichment using oligonucleotide probes and a novel composition of blocking oligonucleotides”. Dr Nick Downey, Integrated DNA Technologies
14.45 – 15.15: Dr Simon Patton, Director European Molecular Genetics Quality Network (EMQN) TITLE: Moving Next Generation Sequencing into Diagnostics: Developing External Quality Assessment (EQA)
15.15 – 15.45: Prof Conrad Lichtenstein, Consultant TITLE: Making the most of Sequencing: Accurate targetted sequencing in pooled populations of 1000′s of DNA samples
15.45 – 16.15: Refreshments, Exhibitions and Networking
16.15 – 16.45: Dr Bas Vroling, Bio-Prodict, Nijmegen, The Netherlands TITLE: Next-generation variant effect predictions and data integration
16.45 – 17.15: Dr Kate Thomson, Principal Clinical Scientist, Oxford Medical Genetics Labs TITLE: Developing NGS strategies for use in a diagnostic setting
19.00: Networking Dinner (by prior booking only)


15.45 – 16.15: Dr Paul Denny, Gene-Effects TITLE: Predicting the effects of sequence variants on phenotype
9.00 – 9.45: Dr Anneke Seller, Director of Genetics Laboratories, Oxford Medical Genetics Labs TITLE: Clinical utility; NGS and the challenge of providing clinically actionable results to aid diagnosis and management of patients and their families
9.45 – 10.15: Prof Magnus Rattray,Computational & Systems Biology, University of Manchester TITLE: Inferring transcript expression levels from RNA-Seq data and scoring differential expression between replicated conditions
10.15 – 10.45: Dr Klaus Brusgaard, Associate Professor Clinical Genetics, Odense University & Director at Amplexa Genetics TITLE:Comparison of NGS Platforms & Software
10.45 – 11.15: Refreshments, Exhibitions and Networking
11.15 – 11.45: Dr Mick Watson, Director of ARK-Genomics, The Roslin Institute, University of Edinburgh TITLE: Deep metagenomic sequencing of multiple rumen guts reveals species-specific microbiomes
11.45 – 12.1 5: Dr Les Mara, Databiology TITLE: Avoiding the Omics Tsunami
12.15 – 12.45: Dr Kim Brugger, Head of Bioinformatics, EASIH, University of Cambridge TITLE: NGS sample analysis, tracking and archiving in a clinical environment
12.45 – 13.45: Lunch, Exhibitions and Networking
13.45 – 14.45: TECHNOLOGY WORKSHOP – “NanoString hypothesis driven research tool drives NGS Discoveries towards the Clinic”.Dr Jim White, NanoString Technologies
14.45 – 15.15: Dr Kevin Blighe, Lead Bioinformatician, Sheffield Children’s NHS Foundation Trust TITLE: Trials and tribulations of enrolling sequencing in Sheffield Children’s Hospital
15.15 – 15.45: Refreshments, Exhibitions and Networking
16.15 – 16.45: Dr Jose Ivorra Martinez, Post-Doctoral Research Fellow, School of Biomedical Sciences, University of Leeds TITLE: Use of Exome Sequencing to identify recessive alleles of major effect predisposing to Schizophrenia in consanguineous and endogamic families
16.45 – 17.00: Closing



PrintIntegrated DNA Technologies (IDT) is a leader in the manufacture and development of products for the research and diagnostic life science market. The largest supplier of custom nucleic acids in the world, IDT serves academic research, biotechnology, and pharmaceutical development communities.

IDT products support a wide variety of applications, including next generation sequencing (NGS), DNA amplification, SNP detection, microarray analysis, expression profiling, gene quantification, and synthetic biology. Platform-independent NGS products and services are available in addition to DNA and RNA oligonucleotides, qPCR assays, siRNA duplexes, and custom gene synthesis. Individually-synthesized xGen™ Lockdown™ Probes enable improved target capture. IDT also manufactures custom adaptors, fusion primers, Molecular Identifier tags (MIDs), and other workflow oligonucleotides for NGS. A TruGrade™ processing service is also available to reduce oligonucleotide crosstalk during multiplex NGS. Serving over 80,000 life sciences researchers, IDT is widely recognized as the industry leader in custom oligonucleotide manufacture due to its unique capabilities. IDT pioneered the use of high throughput quality control (QC) methods and is the only oligonucleotide manufacturer to offer purity guarantees and 100% QC. Every oligonucleotide is analyzed by mass spectrometry and purified oligonucleotides receive further analysis by CE and HPLC. The company maintains an engineering division dedicated to advancing synthesis, processing technology, and automation. An in-house machine shop provides rapid prototyping and custom part design/control. Additionally, IDT offers unrivalled customer support, receiving approximately 100,000 calls annually with an average wait time of only 8 seconds. A dedicated GMP manufacturing facility for molecular diagnostics provides oligonucleotides for In Vitro Diagnostic Devices (IVDs) or Analyte Specific Reagents (ASRs) for Laboratory-Developed Tests (LDTs). This manufacturing process is customer-defined and controlled, and facilitates progression from research to commercialization.


VHBio email Logo SMALLVH Bio is a leading supply and distribution company for the life sciences industry dedicated to consistently delivering quality products and services that will meet and anticipate the needs of the United Kingdom and Republic of Ireland scientific communities. From our headquarters in North-East England, we distribute products for HLA Diagnostics, DNA and RNA Fragment Analysis, Next Gen Sequencing, Molecular Genetics and Oncology Diagnostics, Immunology and Cell Biology. VH Bio has won exclusive UK and ROI rights from Advanced Analytical Technologies, Inc. (AATI) to market the Fragment Analyzer™ Automated Capillary Electrophoresis System for automated rapid and accurate analysis of NGS fragment libraries, intact genomic DNA quality and quantity, as well as total RNA and mRNA. The system also offers multiple gel formulas for SSR/microsatellites and mutation detection (TILLiNG). This exciting new addition to our current product portfolio enables customers to streamline sample analysis by offering high sizing accuracy and superior quantification precision, coupled with a significant reduction in reagent preparation and minimal sample handling compared to manual processes. Please visit our stand to learn how the Fragment Analyzer™ could benefit your laboratory.



SB_lifesciencesSource BioScience is an international diagnostic and genetic analysis services business serving the healthcare and life science research markets. The group has its headquarters in Nottingham, UK where it operates state of the art reference laboratory facilities, with additional UK laboratory facilities in Cambridge, Oxford and Motherwell, and European facilities in Berlin and Dublin. Source BioScience is CPA, GLP and GCP accredited and is licensed by the Human Tissue Authority. Source BioScience Healthcare is a CPA, GLP and GCP accredited provider of healthcare diagnostics including cellular pathology, molecular diagnostics and cytology services to the NHS and other healthcare providers. With state-of-the-art reference laboratory facilities and draws from the expertise of over 60 of the leading RCPath qualified Pathologists. We can offer competitive pricing and provide rapid turnaround on all samples tested. Results are delivered securely via an easy access online portal. A number of the molecular diagnostic tests are companion tests for approved cancer drugs. These tests are available to PharmaBiotech clients in support of clinical trials and clinical research projects. Source BioScience LifeSciences, the European leader in DNA sequencing and genomic services, has launched a new range of life science research products branded reSource™. reSource™ represents a range of high performance and cost effective products expanding the portfolio currently available through Source BioScience’s worldwide commercial network. The first products to be introduced under this brand are nucleic acid purification kits including high quality plasmid mini preps, PCR purification and gel extraction kits suitable for a broad range of applications.


bd_logoBD Biosciences, a segment of Becton, Dickinson and Company, is one of the world’s leading businesses focused on bringing innovative tools to life science researchers and clinicians. Principal product lines include flow cytometers and cell sorters, monoclonal antibodies and kits, reagent systems, tools to aid in drug discovery and diagnostic assays. BD Biosciences customers are involved in basic research, the discovery and development of drugs and vaccines, clinical trials, diagnostic testing, and disease management. This diverse customer base includes academic and government institutions, pharmaceutical and biotech companies, and clinical laboratories.


nanostring-techNanoString Technologies provides innovative products that unlock valuable and clinically actionable genomic information from small amounts of tissue. The company is committed to offering tools that enable scientists and clinicians to translate today’s leading genomic research into clinically actionable tests that improve patient care. For more information see: www.nanostring.com


PrintPerkinElmer is a global provider of technology, services and solutions for applications such as environmental monitoring, food safety, clinical diagnostics and biomedical research. PerkinElmer’s Next Generation Sequencing sample preparation solutions eliminate the processing bottlenecks presented by today’s sequencing technologies. Our automation, microfluidics and bioinformatics platforms enable scientists to process samples start to finish in a user-friendly, easy-to-implement manner. Find out more by visiting www.perkinelmer.com/NGS


StratechlogoCMYKStratech Scientific Ltd provides over 700,000 innovative research tools for life science laboratories. We have built an excellent reputation over 30 years for supplying high quality, competitively priced products. For this conference we have the pleasure in introducing a brand new kit from Affymetrix Inc. the Prep2Seq™ DNA Library Prep Kit, ideal for the generation of high quality next generation sequencing (NGS) libraries suitable for sequencing on Illumina platforms. DNA library prep is critical to the precision and accuracy of NGS. The Prep2Seq DNA Library Prep Kit comes with all the reagents necessary for end repair, A-tailing, and ligation, and can complete in less than two hours. Visit us on our stand to find out more. Our extensive range also includes antibodies (primary and secondary), biochemicals, cells, kits, media and proteins/peptides for research areas such as Immunology, Microbiology and Molecular Cell Biology. To keep up-to-date with new products subscribe to our free newsletter ‘The Probe’ (https://www.stratech.co.uk/subscription) and automatically enter a prize draw to win a tablet PC!




f1researchF1000Research is a completely original open access journal for life scientists; it offers rapid publication, transparent peer review (post publication) and full data deposition and sharing. F1000Research accepts all scientifically sound articles, ranging from single findings, case reports, protocols, replications, and null or negative results to more traditional articles.


Databiology_Logo2Databiology is delivering software products and solutions to make Bioinformatics more robust, scalable and easier to deploy across a diverse range of Scientific environments. As a specialist global business our vision is to be at the forefront of the evolution of enterprise class bioinformatics by providing a full SaaS environment and related business services to support scientific, commercial and clinical applications. We provide secure and industrialised Information Management for Omics environments to: – Enable organizations to create, store, curate, analyse, automate, share and track data in a web based environment – Integrate and complement existing and future NGS & Omics infrastructure investments – Make Omics data assets more secure, portable, searchable, reproducible and reusable – Help improve effectiveness, efficiency, collaboration and compliance across the R&D community Unique in its market positioning, Databiology’s singular commercial objective is to become the market leader in this emerging market by 2015.


BioProdictLogoBio-Prodict is focused on delivering solutions for guiding scientific research in the field of protein engineering, molecular design and DNA diagnostics. We apply novel approaches to data mining, storage and analysis of protein data and combine these with state-of-the art analysis methods and visualization tools to create custom-built 3DM information systems for protein superfamilies. 3DM information systems are designed to facilitate the exploration of sequence-structure-function relations, and have successfully been used many times to elucidate the function of individual amino acids and predict the effects of mutations.

NGS 2013 Manchester

5th & 6th November

Manchester Conference Centre

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November 5, 2013
November 6, 2013

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